|
KMID : 0356820180340020001
|
|
Korean Journal of Head & Neck Oncology
2018 Volume.34 No. 2 p.1 ~ p.9
|
|
|
Impact of positive/close margins in oropharyngeal cancer according to the HPV status
|
|
Jung Yuh-Seok
|
|
|
Abstract
|
|
|
|
With the emerging knowledge about tumor biology specific for human papillomavirus (HPV)-related head and neck cancers, the classical understanding about the curative surgery in head and neck cancers are starting to progress, customized for their HPV-associations and ultimately specific for tumor biologic characteristics. The common rule for surgery should reflect the biologic characteristics of target tumors, but still, multi-institutional large-scale data could be scarce, due to the subjective feature of surgical treatment itself. However, the impact of HPV for margin determination is now being questioned by multiple groups, and typical example is European Cooperative Oncology Group (ECOG)-3311 study. Here, we review the impact of viral association for surgical decision and its biological background and implications.
|
|
|
KEYWORD
|
|
|
Surgery, Margin, Human papillomavirus, p16, De-escal
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|